Protein Details: P2X purinoceptor 7

Protein ID

ICDB_Pro_1420

Protein Name

P2X purinoceptor 7

Gene Name

P2RX7

Organism

Homo sapiens (Human)

Length

595 amino acids

AlphaFoldDB

AF-Q99572-F1-model_v4.pdb

Function

Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells. In the absence of its natural ligand;ATP;functions as a scavenger receptor in the recognition and engulfment of apoptotic cells.

Sequence

MPACCSCSDVFQYETNKVTRIQSMNYGTIKWFFHVIIFSYVCFALVSDKLYQRKEPVISSVHTKVKGIAEVKEEIVENGVKKLVHSVFDTADYTFPLQGNSFFVMTNFLKTEGQEQRLCPEYPTRRTLCSSDRGCKKGWMDPQSKGIQTGRCVVYEGNQKTCEVSAWCPIEAVEEAPRPALLNSAENFTVLIKNNIDFPGHNYTTRNILPGLNITCTFHKTQNPQCPIFRLGDIFRETGDNFSDVAIQGGIMGIEIYWDCNLDRWFHHCRPKYSFRRLDDKTTNVSLYPGYNFRYAKYYKENNVEKRTLIKVFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLAAVFIDFLIDTYSSNCCRSHIYPWCKCCQPCVVNEYYYRKKCESIVEPKPTLKYVSFVDESHIRMVNQQLLGRSLQDVKGQEVPRPAMDFTDLSRLPLALHDTPPIPGQPEEIQLLRKEATPRSRDSPVWCQCGSCLPSQLPESHRCLEELCCRKKPGACITTSELFRKLVLSRHVLQFLLLYQEPLLALDVDSTNSRLRHCAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKSEGQYSGFKSPY

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Leukemia;Chronic Lymphocytic and Leishmaniasis

Location

Widely expressed with highest levels in brain and immune tissues

DOI ID

10.1074/jbc.272.9.5482; 10.1016/j.bbrc.2005.04.087; 10.1038/ng1285; 10.1038/nature04569; 10.1101/gr.2596504; 10.1093/emboj/20.22.6347; 10.1074/jbc.m205120200; 10.1096/fj.08-114637; 10.1021/bi902083n; 10.4049/jimmunol.1101178; 10.1016/j.jprot.2013.11.014; 10.1074/jbc.m010353200; 10.1074/jbc.m212759200; 10.1074/jbc.m313902200; 10.1126/science.1133427; 10.1096/fj.12-215368; 10.1002/humu.23218

RefSeq

NP_002553.3 [Q99572-1]; XP_011536722.1